A year after the death of his friend and partner Sherlock Holmes at the hands of Moriarty, Dr. John Watson resumes his medical career as the head of a clinic dedicated to treating rare disorders. However, he soon finds that his old life is not done with him yet.

Morris Chestnutas Dr. John Watson
Eve Harlowas Dr. Ingrid Derian
Peter Mark Kendallas Dr. Stephens Croft / Dr. Adam Croft
Inga Schlingmannas Dr. Sasha Lubbock
Ritchie Costeras Shinwell Johnson
Rochelle Aytesas Dr. Mary Morstan
Anjelica Bette Fellinias Erika Filipello
Shannon Berryas Autumn Franco
Jean Zarzouras Erika's Mother
Craig Sweeny
Samuel Evan Horowitz
Bashir Gavriel