The Golden Palace begins where The Golden Girls had ended, in the quartet's now-sold Miami house. With Dorothy Zbornak having married and left in the previous series finale, the three remaining cast members (Dorothy's mother, Sophia Petrillo, Rose Nylund, and Blanche Devereaux) decide to invest in a Miami hotel that is up for sale. The hotel, however, is revealed to have been stripped of all of its personnel in an effort to appear more profitable, leaving only two employees: Roland Wilson, the hotel's manager, and Chuy Castillos, the hotel's chef. This requires the women to perform all the tasks of the hotel's staff.

Betty Whiteas Rose Nylund
Rue McClanahanas Blanche Devereaux
Estelle Gettyas Sophia Petrillo
Don Cheadleas Roland Wilson
Cheech Marinas Chuy Castillos
Billy L. Sullivanas Oliver Webb
Harold Gouldas Miles Webber
Bea Arthuras Dorothy Hollingsworth
Bobcat Goldthwaitas Gordon M. Cosay
George Burnsas George Burns
Marc Cherry
Mitchell Hurwitz
Marco Pennette
Susan Harris
Jonathan Schmock
George Aliceson Tipton