4400 centers on the return of 4400 people who, previously presumed dead or reported missing, reappear on Earth. Though they have not aged physically, some of them seem to have deeper alterations ranging from superhuman strength to an unexplained healing touch. A government agency is formed to track the 4400 people after one of them commits a murder.

Samantha Ferrisas Nina Jarvis
Jacqueline McKenzieas Diana Skouris
Joel Gretschas Tom Baldwin
Patrick John Fluegeras Shawn Farrell
Karina Lombardas Alana Mareva
Megalyn Echikunwokeas Isabelle Tyler
Chad Faustas Kyle Baldwin
Lori Trioloas Linda Baldwin
Mahershala Alias Richard Tyler
Peter Coyoteas Dennis Ryland
Craig Sweeny
Ira Steven Behr
Amy Berg
Scott Peters
Bruce Miller
Doug Petrie
George S. Clinton