Twenty-four-year-old Kara Zor-El, who was taken in by the Danvers family when she was 13 after being sent away from Krypton, must learn to embrace her powers after previously hiding them. The Danvers teach her to be careful with her powers, until she has to reveal them during an unexpected disaster, setting her on her journey of heroism.

Melissa Benoistas Kara Danvers / Supergirl / Kara Zor-El
Chyler Leighas Alex Danvers / Sentinel
David Harewoodas J'onn J'onzz / Martian Manhunter
Katie McGrathas Lena Luthor
Jesse Rathas Querl 'Brainy' Dox / Brainiac-5
Nicole Mainesas Nia Nal / Dreamer
Floriana Limaas Maggie Sawyer
Azie Tesfaias Kelly Olsen / Guardian
Julie Gonzaloas Andrea Rojas / Acrata
Staz Nairas William Dey
Jessica Queller
Gabriel Llanas
Andrew Kreisberg
Jay Faerber
Greg Berlanti
J. Holtham
Rachel Shukert
Michael Grassi
Ali Adler
Roberto Aguirre-Sacasa
Marc Guggenheim
Maria Maggenti
Azie Tesfai
Blake Neely