Perhaps their strikingly different personalities make the relationship between detective Jane Rizzoli and medical examiner Maura Isles so effective. Jane, the only female cop in Boston's homicide division, is tough, relentless and rarely lets her guard down, while the impeccably dressed Maura displays a sometimes icy temperament — she is, after all, more comfortable among the dead than the living. Together, the best friends have forged a quirky and supportive relationship; they drop the protective shield in each other's company, and combine their expertise to solve Boston's most complex cases.

Angie Harmonas Detective Jane Rizzoli
Sasha Alexanderas Dr. Maura Isles
Jordan Bridgesas Frankie Rizzoli Jr.
Lee Thompson Youngas Detective Barry Frost
Bruce McGillas Detective Vince Korsak
Lorraine Braccoas Angela Rizzoli
Tina Huangas Susie Chang
Chris Vanceas Charles 'Casey' Jones
Idara Victoras Nina Holiday
Heather Tomas Mrs. Tolliver
Janet Tamaro
Dee Johnson
Elizabeth Benjamin
Julie Hébert