Pinky and Brain are genetically enhanced laboratory mice who reside in a cage in the Acme Labs research facility. Brain is self-centered and scheming; Pinky is good-natured but feebleminded. In each episode, Brain devises a new plan to take over the world, which ultimately ends in failure, usually due to Pinky's idiocy, the impossibility of Brain's plan, Brain's own arrogance, or just circumstances beyond their control.

Charles M. Howell IV
Gordon Bressack
Peter Hastings
Dave Finkel
Brett Baer
Tom Ruegger
Patric M. Verrone
Norm McCabe
Paul Rugg
David Fury
Brian Swenlin