A Victorian-era Toronto detective uses then-cutting edge forensic techniques to solve crimes, with the assistance of a female coroner who is also struggling for recognition in the face of tradition, based on the books by Maureen Jennings.

Yannick Bissonas Detective William Murdoch
Helene Joyas Dr. Julia Ogden
Thomas Craigas Chief Constable Thomas Brackenreid
Jonny Harrisas Constable George Crabtree
Lachlan Murdochas Constable Henry Higgins
Georgina Reillyas Dr. Emily Grace
Daniel Maslanyas Detective Llewellyn Watts
Paul Rhysas Dr. Llewllyn Francis
Shanice Bantonas Violet Hart
Jonathan Wattonas Dr. Darcy Garland
Laura Phillips
Jason Sherman
Alexandra Zarowny
Robert Carli