An insecure but courageous and intelligent teen named Peter Parker, a new student of Midtown High, is bitten by a radioactive spider and given powers. He becomes a hero named Spider-Man after the death of his uncle and he must adapt to this new way of life.

Patton Oswaltas Uncle Ben (voice)
Jim Cummingsas Hammerhead (voice)
Nadji Jeteras Miles Morales (voice)
Alastair Duncanas Adrian Toomes (voice)
Robbie Daymondas Peter Parker / Spider-Man (voice)
John DiMaggioas Raymond Warren (voice)
Nancy Linarias Aunt May (voice)
Max Mittelmanas Harry Osborn (voice)
Melanie Minichinoas Anya Corazon (voice)
Ben Diskinas Flash Thompson
Kevin Shinick
Kevin Burke
Chris Wyatt
Brian Tyler