13 years after being impregnated by Satan, a reluctant mother, Laura, and her Antichrist daughter, Chrissy, attempt to live an ordinary life in Delaware, but are constantly thwarted by monstrous forces, including Satan, who yearns for custody of his daughter's soul.

Aubrey Plazaas Laura Feinberg (voice)
Lucy DeVitoas Chrissy Feinberg (voice)
Danny DeVitoas Satan (voice)
Michael Shannonas Unshaven Man (voice)
D.J. 'Shangela' Pierceas Queen Inichoochiama (voice)
Arnold Schwarzeneggeras Game Show Host (voice)
Laci Mosleyas Librarian / Townsperson (voice)
Eugene Corderoas Bennigan (voice)
Seth Kirschner
Darcy Fowler
Karey Dornetto
Lillian Yu