Nono Hana is a middle school student who encounters a baby named Hug-tan and her guardian, Harry, who fell from the sky. Hana learns that they have been pursued by the evil Criasu Corporation, who wants Hug-tan's Mirai Crystal and change the present. Protecting Hug-tan causes Hana to gain her own Mirai Crystal and transform into the Pretty Cure of High Spirits, Cure Yell.

Rie Hikisakaas Hana Nono / Cure Yell (voice)
Rina Honnizumias Saaya Yakushiji / Cure Ange (voice)
Yui Oguraas Homare Kagayaki / Cure Étoile (voice)
Nao Tamuraas Emiru Aisaki / Cure Macherie (voice)
Yukari Tamuraas Lulu Amour / Cure Amour (voice)
Konomi Tadaas Hug-tan (voice)
Junko Nodaas Hariham Harry (voice)
Jun Fukushimaas Hariham Harry (human) (voice)
Yoko Honnaas Nagisa Misumi / Cure Black (voice)
Yukanaas Honoka Yukishiro / Cure White (voice)
Fumi Tsubota
Akiko Inoue
Yuki Hayashi