The Earth has been targeted for invasion by the alien Cthuwulf. A young girl, Nagisa Kano, becomes the key to Earth's defense when she is forced to become the partner of Iczer-One, a lone rebel who is battling the alien invaders.

Cutie Suzukias Iczer-3 (voice)
Yuri Shiratorias Nagisa Kasumi (voice)
Yuriko Yamamotoas Iczer-1 (voice)
Kaneto Shiozawaas Big Gold / Sir Violet (voice)
Keiko Todaas Iczer-2 (voice)
Mayumi Shouas Nagisa Kanō (voice)
Naoko Watanabeas Sayoko (voice)
Sumi Shimamotoas Sir Violet (voice)
Ikuya Sawakias Space Station Commander (voice)
Chumei Watanabe