In 2071, roughly fifty years after an accident with a hyperspace gateway made the Earth almost uninhabitable, humanity has colonized most of the rocky planets and moons of the Solar System. Amid a rising crime rate, the Inter Solar System Police (ISSP) set up a legalized contract system, in which registered bounty hunters, also referred to as "Cowboys", chase criminals and bring them in alive in return for a reward.

Koichi Yamaderaas Spike Spiegel / Ein (voice)
Unsho Ishizukaas Jet Black (voice)
Megumi Hayashibaraas Faye Valentine (voice)
Aoi Tadaas Edward Wong Hau Pepelu Tivruski IV (voice)
Takeshi Aonoas Doohan (voice)
Norio Wakamotoas Vicious (voice)
Gara Takashimaas Julia (voice)
Rintaro Nishias Asimov Solensan (voice) (as Tarô Nishi)
Yurika Hinoas Katrina Solensan (voice)
Takehiro Koyamaas Laughing Bull (voice)
Keiko Nobumoto
Sadayuki Murai
Dai Sato
Shinichiro Watanabe
Yoko Kanno