City Homicide follows a group of detectives in the Homicide department of Melbourne's Metropolitan Police Headquarters.

Daniel MacPhersonas Detective Senior Constable Simon Joyner
David Fieldas Terry Jarvis
Shane Bourneas Detective Senior Sergeant Stanley Wolfe
Noni Hazlehurstas Commander Bernice Waverley
Nadine Garneras Detective Senior Constable Jennifer Mapplethorpe
Damien Richardsonas Detective Sergeant Matt Ryan
Aaron Pedersenas Detective Senior Constable Duncan Freeman
Fiona Corkeas Judith Welling
Martin Blumas Steve Rickards