The series is set in a universe inhabited solely by anthropomorphic animals of many species and focuses on a trio of campers attending a poorly run summer camp known as Camp Kidney. The trio consists of Lazlo, the eccentric, optimistic spider monkey; Raj, the timid Indian elephant; and Clam, the quiet albino pygmy rhinoceros, and their multiple surreal misadventures.

Steve Littleas Chip / Skip (voice)
Carlos Alazraquias Lazlo / Clam / Chef McMuesli (voice)
Mr. Lawrenceas Edward / Dave / Ping Pong / Nurse Leslie (voice)
Jeff Bennettas Raj / Samson / Commander Hoo-Ha (voice)
Tom Kennyas Scoutmaster Lumpus / Slinkman (voice)
Alan Young
Billy West
Jill Talleyas Gretchen / Nina Neckley / Ms. Mucus (voice)
Jodi Bensonas Patsy Smiles (voice)
Steve Little
Kent Osborne
Martin Olson
J.G. Quintel
Joe Murray
Thurop Van Orman
Kim Roberson
Eddie Trigueros
Tuck Tucker
Derek Drymon