The gang decide to go traveling in the Mystery Machine, seeking fun and adventure during what could possibly be their last summer break together. However, havoc-wreaking monsters seem to be drawn to them, appearing almost every stop of the way.

Matthew Lillardas Shaggy Rogers (voice)
Grey DeLisleas Daphne Blake (voice)
Kate Micuccias Velma Dinkley (voice)
Frank Welkeras Fred Jones / Scooby-Doo (voice)
Chord Overstreetas Mitchell / Andrew (voice)
JB Blancas Vic / Colander (voice)
Laraine Newmanas Professor Salazar / Running Girl / Female Security Guard (voice)
Kiff Schollas Jeff / Male Security Guard (voice)
Edward Boscoas Werewolf (voice)
Candi Miloas Ms. Tuckle (voice)