Legless Southern inventor Dr. Arliss Loveless plans to rekindle the Civil War by assassinating President Ulysses S. Grant. Only two men can stop him: gunfighter James West and master-of-disguise and inventor Artemus Gordon. The two must team up to thwart Loveless' plans.

Will Smithas Capt. James West
Kevin Klineas U.S. Marshal Artemus Gordon / President Grant
Kenneth Branaghas Dr. Arliss Loveless
Salma Hayek Pinaultas Rita Escobar
M. Emmet Walshas Coleman
Ted Levineas General 'Bloodbath' McGrath
Frederique van der Walas Amazonia
Musetta Vanderas Munitia
Sofia Engas Miss Lippenrieder
Bai Lingas Miss Mae Lee East
Michael Ballhaus