When beautiful Carla Purty joins the university faculty, genetic professor Dr. Sherman Klump grows desperate to whittle his 400-pound frame down to size and win her heart. So, with one swig of his experimental fat-reducing serum, Sherman becomes 'Buddy Love', a fast-talking, pumped-up, plumped down Don Juan.

Eddie Murphyas Sherman Klump / Buddy Love / Lance Perkins / Papa Klump / Mama Klump / Grandma Klump / Ernie Klump
Jada Pinkett Smithas Carla Purty
James Coburnas Harlan Hartley
Larry Milleras Dean Richmond
Dave Chappelleas Reggie Warrington
John Alesas Jason
Patricia Wilsonas Dean's Secretary
Jamal Mixonas Ernie Klump, Jr.
Nichole McAuleyas Fit Woman
Hamilton von Wattsas Health Instructor
Julio Macat