After experimenting on himself and becoming invisible, scientist Jack Griffin, now aggressive due to the drug's effects, seeks a way to reverse the experiment at any cost.

Claude Rainsas Dr. Jack Griffin
Gloria Stuartas Flora Cranley
William Harriganas Dr. Arthur Kemp
Henry Traversas Dr. Cranley
Una O'Connoras Jenny Hall
Forrester Harveyas Herbert Hall
Holmes Herbertas Chief of Police
E. E. Cliveas Constable Jaffers
Dudley Diggesas Chief Detective
Harry Stubbsas Inspector Bird