Lincoln Rhyme was the department's top homicide detective and leading expert in criminal forensics until an injury left him paralyzed, depressed, and incapable of working. But when a gruesome murder in Manhattan leaves detectives baffled, they call on Rhyme to help solve the mystery. Amelia Donaghy, a rookie cop whose quick thinking preserved a gruesome murder scene, is enlisted by Rhyme to be his on-the-scene forensics expert. With Amelia reluctantly acting as Rhyme's able-bodied go-between, the pair piece together cryptic clues the killer leaves behind at the scene of the crime, hoping to catch the grisly serial killer.

Denzel Washingtonas Lincoln Rhyme
Angelina Jolieas Amelia Donaghy
Queen Latifahas Thelma
Michael Rookeras Captain Howard Cheney
Michael McGloneas Detective Kenny Solomon
Luis Guzmánas Eddie Ortiz
Leland Orseras Richard Thompson
John Benjamin Hickeyas Dr. Barry Lehman
Bobby Cannavaleas Steve, Amelia's Boyfriend
Ed O'Neillas Detective Paulie Sellitto
Dean Semler