The seemingly invincible Spider-Man goes up against an all-new crop of villains—including the shape-shifting Sandman. While Spider-Man’s superpowers are altered by an alien organism, his alter ego, Peter Parker, deals with nemesis Eddie Brock and also gets caught up in a love triangle.

Tobey Maguireas Spider-Man / Peter Parker
Kirsten Dunstas Mary Jane Watson
James Francoas New Goblin / Harry Osborn
Thomas Haden Churchas Sandman / Flint Marko
Topher Graceas Venom / Eddie Brock
Bryce Dallas Howardas Gwen Stacy
Rosemary Harrisas May Parker
J.K. Simmonsas J. Jonah Jameson
James Cromwellas Captain Stacy
Dylan Bakeras Dr. Curt Connors
Bill Pope