After being bitten by a genetically altered spider at Oscorp, nerdy but endearing high school student Peter Parker is endowed with amazing powers to become the superhero known as Spider-Man.

Tobey Maguireas Spider-Man / Peter Parker
Willem Dafoeas Green Goblin / Norman Osborn
Kirsten Dunstas Mary Jane Watson
James Francoas Harry Osborn
Cliff Robertsonas Ben Parker
Rosemary Harrisas May Parker
J.K. Simmonsas J. Jonah Jameson
Joe Manganielloas Flash Thompson
Gerry Beckeras Maximilian Fargas
Bill Nunnas Joseph 'Robbie' Robertson
Don Burgess