Peter Parker is going through a major identity crisis. Burned out from being Spider-Man, he decides to shelve his superhero alter ego, which leaves the city suffering in the wake of carnage left by the evil Doc Ock. In the meantime, Parker still can't act on his feelings for Mary Jane Watson, a girl he's loved since childhood. A certain anger begins to brew in his best friend Harry Osborn as well...

Tobey Maguireas Spider-Man / Peter Parker
Kirsten Dunstas Mary Jane Watson
James Francoas Harry Osborn
Alfred Molinaas Doc Ock / Otto Octavius
Rosemary Harrisas May Parker
J.K. Simmonsas J. Jonah Jameson
Donna Murphyas Rosalie Octavius
Daniel Gilliesas John Jameson
Dylan Bakeras Dr. Curt Connors
Bill Nunnas Joseph 'Robbie' Robertson
Bill Pope