A group of rebels travel the outskirts of space evading the sinister Alliance regime. Their lives of smuggling and cargo-running are interrupted by a psychic passenger who harbours a dangerous secret. Soon, the crew find themselves being pursued by an Alliance agent who will stop at nothing to find them.

Nathan Fillionas Malcolm 'Mal' Reynolds
Summer Glauas River Tam
Gina Torresas Zoë Alleyne Washburne
Alan Tudykas Hoban 'Wash' Washburne
Morena Baccarinas Inara Serra
Adam Baldwinas Jayne Cobb
Jewel Staiteas Kaywinnet Lee 'Kaylee' Frye
Sean Maheras Simon Tam
Ron Glassas Shepherd Derrial Book
Chiwetel Ejioforas The Operative
Jack N. Green