When the Justice League goes missing and villains overrun Metropolis, there's only one team that can solve this mystery: Scooby-Doo and the gang! But wait, there's a new dog in town – Krypto – Superman's Superdog with Super Powers. Mystery Inc. will need all the help it can get when phantoms menace the Justice League's headquarters.

Frank Welkeras Scooby-Doo / Fred Jones (voice)
Grey DeLisleas Daphne Blake / Wonder Woman (voice)
Matthew Lillardas Shaggy Rogers (voice)
Kate Micuccias Velma Dinkley (voice)
P.J. Byrneas J.B. (voice)
Victoria Graceas Mercy (voice)
Charles Halfordas Lex Luthor (voice)
Nolan Northas Computer / Joker / Superman (voice)
Tara Strongas Helen / Lois Lane / Harley Quinn (voice)
Fred Tatascioreas Solomon Grundy / Perry White (voice)