A medical examiner discovers that an innocent shooting victim in a robbery died of bubonic plague. With only 48 hours to find the killer, who is now a ticking time bomb threatening the entire city, a grisly manhunt through the seamy underworld of the New Orleans Waterfront is underway.

Richard Widmarkas Lt. Cmdr. Clinton 'Clint' Reed M.D.
Paul Douglasas Capt. Tom Warren
Barbara Bel Geddesas Nancy Reed
Jack Palanceas Blackie
Zero Mostelas Raymond Fitch
Dan Rissas Neff - Newspaper Reporter
Tommy Cookas Vince Poldi - Younger Brother
Lewis Charlesas Kochak - Murder Victim (uncredited)