A white blood cell policeman, with the help of a cold pill, must stop a deadly virus from destroying the human they live in, Frank.

Chris Rockas Osmosis Jones (voice)
Laurence Fishburneas Thrax (voice)
David Hyde Pierceas Drix (voice)
Brandy Norwoodas Leah (voice)
Elena Franklinas Shane Detorre
Bill Murrayas Frank Detorre
William Shatneras Mayor Phlegmming (voice)
Ron Howardas Tom Colonic (voice)
Kid Rockas Kidney Rock (voice)
Molly Shannonas Mrs. Boyd
Mark Irwin