A series of interconnected short films are the backdrop for a maniac screenwriter who pitches insane storylines featuring some of Hollywood's biggest and brightest. In some countries, like the United Kingdom and the Netherlands, the structure differs. Instead of a pitch, the films are connected by a group of three teenagers searching for the most banned film in the world, Movie 43, which will ultimately lead to the destruction of civilization.

Dennis Quaidas Charlie Wessler (segment "The Pitch")
Greg Kinnearas Griffin Schraeder (segment "The Pitch")
Hugh Jackmanas Davis (segment "The Catch")
Kate Winsletas Beth (segment "The Catch")
Jeremy Allen Whiteas Kevin (segment "Homeschooled")
Liev Schreiberas Robert (segment "Homeschooled")
Naomi Wattsas Samantha (segment "Homeschooled")
Anna Farisas Vanessa (segment "The Proposition")
Chris Prattas Jason (segment "The Proposition")
Kieran Culkinas Neil (segment "Veronica")
Frankie DeMarco
Steve Gainer
Matthew F. Leonetti
William Rexer
Newton Thomas Sigel
Daryn Okada
Mattias Rudh