When Susan Murphy is unwittingly clobbered by a meteor full of outer space gunk on her wedding day, she mysteriously grows to 49-feet-11-inches. The military jumps into action and captures Susan, secreting her away to a covert government compound. She is renamed Ginormica and placed in confinement with a ragtag group of Monsters...

Reese Witherspoonas Susan Murphy / Ginormica (voice)
Seth Rogenas B.O.B. (voice)
Hugh Laurieas Dr. Cockroach Ph.D. (voice)
Rainn Wilsonas Gallaxhar (voice)
Will Arnettas The Missing Link (voice)
Kiefer Sutherlandas General W.R. Monger (voice)
Paul Ruddas Derek Dietl (voice)
Stephen Colbertas President Hathaway (voice)
Julie Whiteas Wendy Murphy (voice)
Jeffrey Tamboras Carl Murphy (voice)