Megamind's former villain team, The Doom Syndicate, has returned. Our newly crowned blue hero must now keep up evil appearances until he can assemble his friends (Roxanne, Ol' Chum and Keiko) to stop his former evil teammates from launching Metro City to the Moon.

Keith Fergusonas Megamind (voice)
Laura Postas Roxanne Ritchi (voice)
Josh Breneras OI' Chum (voice)
Maya Tuttleas Keiko Morita (voice)
Emily Tuñonas Lady Doppler (voice)
Talon Warburtonas Lord Nighty-Knight (voice)
Scott Adsitas Pierre Pressure (voice)
Chris Sullivanas Behemoth (voice)
Tony Haleas Mel / Mr. Donut / TV Announcer (voice)
Adam Lambertas Machiavillain (voice)