Two bounty hunters both pursue the brutal and sadistic bandit, El Indio, who has a large bounty on his head.

Clint Eastwoodas Manco
Lee Van Cleefas Col. Douglas Mortimer
Gian Maria Volontéas El Indio
Luigi Pistillias Groggy, Member of Indio's Gang
Klaus Kinskias Juan Wild - The Hunchback
Luis Rodríguezas Manuel, Member of Indio's Gang
Benito Stefanellias Luke 'Hughie'
Aldo Sambrellas Cuchillo
Massimo Dallamano