When The Man in the Yellow Hat befriends Curious George in the jungle, they set off on a non-stop, fun-filled journey through the wonders of the big city toward the warmth of true friendship.

Will Ferrellas Ted (Man with the Yellow Hat) (voice)
Drew Barrymoreas Maggie (voice)
David Crossas Junior (voice)
Eugene Levyas Clovis (voice)
Joan Plowrightas Ms. Plushbottom (voice)
Dick Van Dykeas Mr. Bloomsberry (voice)
Frank Welkeras George (voice)
Ed O'Rossas Ivan (voice)
Michael Sorichas "Seen It" Cab Driver (voice)