Prince Akeem Joffer is set to become King of Zamunda when he discovers he has a son he never knew about in America – a street savvy Queens native named Lavelle. Honoring his royal father's dying wish to groom this son as the crown prince, Akeem and Semmi set off to America once again.

Eddie Murphyas Prince Akeem / Clarence / Saul / Randy Watson
Leslie Jonesas Mary Junson
Arsenio Hallas Semmi / Morris / Reverend Brown / Baba
Teyana Tayloras Bopoto
Wesley Snipesas General Izzi
Shari Headleyas Lisa
Morgan Freemanas Morgan Freeman
John Amosas Cleo McDowell
Tracy Morganas Uncle Reem
KiKi Layneas Meeka