When a professor develops a vaccine that eliminates human allergies to dogs, he unwittingly upsets the fragile balance of power between cats and dogs and touches off an epic battle for pet supremacy. The fur flies as the feline faction, led by Mr. Tinkles, squares off against wide-eyed puppy Lou and his canine cohorts.

Jeff Goldblumas Professor Brody
Elizabeth Perkinsas Mrs. Brody
Alexander Pollockas Scotty Brody
Miriam Margolyesas Sophie the Castle Maid
Tobey Maguireas Lou the Beagle (voice)
Alec Baldwinas Butch (voice)
Sean Hayesas Mr. Tinkles (voice)
Susan Sarandonas Ivy (voice)
Joe Pantolianoas Peek (voice)
Michael Clarke Duncanas Sam (voice)
Julio Macat