Detectives Marcus Burnett and Mike Lowrey of the Miami Narcotics Task Force are tasked with stopping the flow of the drug Ecstasy into Miami. They track the drugs to the whacked-out Cuban drug lord Johnny Tapia, who is also involved in a bloody war with Russian and Haitian mobsters. If that isn't bad enough, there's tension between the two detectives when Marcus discovers that playboy Mike is secretly romancing Marcus’ sister, Syd.

Martin Lawrenceas Detective Marcus Burnett
Will Smithas Detective Mike Lowrey
Jordi Mollàas Hector Juan Carlos 'Johnny' Tapia
Gabrielle Unionas Syd
Peter Stormareas Alexei
Theresa Randleas Theresa
Joe Pantolianoas Captain Howard
Michael Shannonas Floyd Poteet
Jon Sedaas Roberto
Yul Vazquezas Detective Mateo Reyes
Amir Mokri