Marcus Burnett is a henpecked family man. Mike Lowrey is a footloose and fancy free ladies' man. Both Miami policemen, they have 72 hours to reclaim a consignment of drugs stolen from under their station's nose. To complicate matters, in order to get the assistance of the sole witness to a murder, they have to pretend to be each other.

Will Smithas Mike Lowrey
Martin Lawrenceas Marcus Burnett
Téa Leonias Julie Mott
Tchéky Karyoas Fouchet
Joe Pantolianoas Captain Howard
Theresa Randleas Theresa Burnett
Marg Helgenbergeras Alison Sinclair
Nestor Serranoas Detective Sanchez
Julio Oscar Mechosoas Detective Ruiz