In 1839, the slave ship Amistad set sail from Cuba to America. During the long trip, Cinque leads the slaves in an unprecedented uprising. They are then held prisoner in Connecticut, and their release becomes the subject of heated debate. Freed slave Theodore Joadson wants Cinque and the others exonerated and recruits property lawyer Roger Baldwin to help his case. Eventually, John Quincy Adams also becomes an ally.

Morgan Freemanas Theodore Joadson
Nigel Hawthorneas Martin Van Buren
Anthony Hopkinsas John Quincy Adams
Djimon Hounsouas Cinque
Matthew McConaugheyas Roger Sherman Baldwin
David Paymeras Secretary John Forsyth
Pete Postlethwaiteas Holabird
Stellan Skarsgårdas Tappan
Razaaq Adotias Yamba
Janusz Kamiński