It is 1967, and Larry Gopnik, a physics professor at a quiet Midwestern university, has just been informed by his wife Judith that she is leaving him. He scrambles to find a semblance of meaning as he loses control of nearly every aspect of his life.

Michael Stuhlbargas Larry Gopnik
Richard Kindas Uncle Arthur
Fred Melamedas Sy Ableman
Sari Lennickas Judith Gopnik
Aaron Wolffas Danny Gopnik
Peter Breitmayeras Mr. Brandt
Roger Deakins