Three outlaws on the run discover a dying woman and her baby. They swear to bring the infant to safety across the desert, even at the risk of their own lives.

John Wayneas Robert Marmaduke Sangster Hightower
Pedro Armendárizas Pedro 'Pete' Roca Fuerte
Harry Carey Jr.as William Kearney ('The Abilene Kid')
Ward Bondas Perley 'Buck' Sweet
Mae Marshas Mrs. Perley Sweet
Mildred Natwickas The Mother
Jane Darwellas Miss Florie
Guy Kibbeeas Judge
Dorothy Fordas Ruby Latham
Ben Johnsonas Posse man #1