It is April 1900, in the Levant, on the imaginary island of Mingheria-the twenty-ninth state of the Ottoman Empire-located in the eastern Mediterranean between Crete and Cyprus. Half the population is Muslim, the other half are Orthodox Greeks, and tension is high between the two. When a plague arrives-brought either by Muslim pilgrims returning from the Mecca or by merchant vessels coming from Alexandria-the island revolts. To stop the epidemic, the Ottoman sultan Abdul Hamid II sends his most accomplished quarantine expert to the island-an Orthodox Christian. Some of the Muslims, including followers of a popular religious sect and its leader Sheikh Hamdullah, refuse to take precautions or respect the quarantine. And then a murder occurs. As the plague continues its rapid spread, the Sultan sends a second doctor to the island, this time a Muslim, and strict quarantine measures are declared. But the incompetence of the island's governor and local administration and the people's refusal to respect the bans ...